ER Analyte ControlDR
Our ER Dynamic Range Analyte Control contains four cores, offering a full range of expression for ER: Negative, Low, Intermediate, and High.
Negative
Low
Intermediate
High
Estrogen receptor has long been a target for treatment in breast cancer, with the greatest impact occurring with the introduction of Tamoxifen.
Tamoxifen is a selective ER modulator (SERM) as it binds to ER causing dimerization yet does not induce the same recruitment of co-activators as the estrogens do. Newer therapies such as the aromatase inhibitors (AI) have demonstrated a greater effectiveness in both the adjuvant and metastatic setting.
The Dynamic Range contains a negative, low (Allred 2/3), intermediate (Allred 5/6) and high (Allred 8) range of expression. This range of staining provides a degree of sensitivity allowing for greater quality control.
